REVIEW: STABILITY OF SOLID SNEDDS FORMULA IN VARIOUS EXCIPIENTS AND MANUFACTURING METHOD

Abstract

The stability of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) remains a significant challenge in oral drug formulation, as liquid SNEDDS often suffer from leakage and chemical instability during storage. Transforming these systems into solid SNEDDS (S-SNEDDS) has emerged as a promising approach to combine the enhanced solubility and bioavailability of nanoemulsified systems with the physical and chemical stability of solid dosage forms. This review comprehensively examines the stability profiles of S-SNEDDS formulations produced using various solidifying agents and manufacturing methods. The discussion focuses on adsorption to solid carriers, spray drying, and freeze-drying techniques while comparing the effects of different adsorbents, such as amorphous silica derivatives Aerosil, Sylysia, and Neusilin, on the stability outcomes. Literature was systematically gathered from databases including PubMed, ScienceDirect, and Google Scholar, covering original studies published between 2011 and 2023 that reported short- and long-term stability. The synthesis of the reviewed data indicates that adsorption onto solid carriers, particularly silica-based excipients, provides the most stable S-SNEDDS formulations. These preparations maintained consistent globule size, drug content, dissolution profile, and absence of phase separation under accelerated and long-term storage conditions. Factors such as high oil absorption capacity and porosity of the adsorbent were key determinants of the flowability and stability of the resulting powder. In conclusion, this review highlights that silica-based adsorbents, especially Sylysia and Neusilin, confer superior stability to S-SNEDDS compared with other materials ...